产品货号：
Z16762
中文名称：
FBXW7抗体
英文名称：
Anti-FBXW7 antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-FBXW7 antibody |
| 指标别名 | AGO;Archipelago homolog;CDC4;F box protein FBX30;FBW6;FBW7;FBX30;FBXO30;FBXW6;FBXW7;hAgo;hCdc4;SEL 10;SEL10 |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse |
| 应用范围 | WB,IHC,ELISA |
| 基因名称 | FBXW7 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | E.coli-derived human FBXW7 recombinant protein (Position:M1-P231). |
| 实际分子量 | 100～110KD,66～75KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif,the F-box.The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box),which function in phosphorylation-dependent ubiquitination.The F-box proteins are divided into 3 classes:Fbws containing WD-40 domains,Fbls containing leucine-rich repeats,and Fbxs containing either different protein-protein interaction modules or no recognizable motifs.The protein encoded by this gene was previously referred to as FBX30,and belongs to the Fbws class;in addition to an F-box,this protein contains 7 tandem WD40 repeats.This protein binds directly to cyclin E and probably targets cyclin E for ubiquitin-mediated degradation.Mutations in this gene are detected in ovarian and breast cancer cell lines,implicating the gene's potential role in the pathogenesis of human cancers.Multiple transcript variants encoding different isoforms have been found for this gene. |
| Uniprot ID | Q969H0 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P) and ICC. |
| 基因名全称 | F-box and WD repeat domain containing 7 |
| 蛋白名全称 | F-box/WD repeat-containing protein 7 |
| 推荐稀释比 | Western blot (WB) 1:500～2000 Immunohistochemistry (IHC) 1:50～400 Enzyme linked immunosorbent assay (ELISA) 1:100～1000 (Boiling the paraffin sections in 10mM citrate buffer,pH6.0,or PH8.0 EDTA repair liquid for 20 mins is required for the staining of formalin/paraffin sections.) Optimal working dilutions must be determined by end user. |
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